Small molecules which mimic SIN3A knock-down (with LIF agent treatment)
Canned Analysis
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General Information
AccessionDCA00020141
TitleSmall molecules which mimic SIN3A knock-down (with LIF agent treatment)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SIN3A knock-down (with LIF agent treatment) in the MCF7 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20446e467bea600fba35c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsolomoniyi
CREEDS IDgene:1249
Cell TypeMCF7
Gene Symbol (human)SIN3A
Gene Symbol (mouse)Sin3a
Organismhuman
Perturbation Typeknock-down (with LIF agent treatment)
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM873554, GSM873557
Perturbed SamplesGSM873559, GSM873563
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE35696
Gene Expression Omnibus
Leukemia inhibitory factor effect on Sin3a-silenced MCF7 breast cancer cell line
21
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