Small molecules which mimic PTEN KD
Canned Analysis
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General Information
AccessionDCA00020191
TitleSmall molecules which mimic PTEN KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PTEN KD in the HCC827 - NON-SMALL CELL LUNG carcinoma cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d230eee467bea600fbb6d0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:127
Cell TypeHCC827 - NON-SMALL CELL LUNG carcinoma cell line
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM183436, GSM183437
Perturbed SamplesGSM183438, GSM183439
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE7562
Gene Expression Omnibus
Tumor suppressor PTEN depletion effect on various cell lines
21
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