Small molecules which mimic PTEN KO
Canned Analysis
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General Information
AccessionDCA00020215
TitleSmall molecules which mimic PTEN KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PTEN KO in the Analysis of prostate tumors from mutants with prostate-specific Pten loss cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20e83e467bea600fba7e4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:1281
Cell TypeAnalysis of prostate tumors from mutants with prostate-specific Pten loss
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM856048, GSM856049, GSM856050
Perturbed SamplesGSM856051, GSM856052, GSM856053
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34839
Gene Expression Omnibus
Pten-null, K-ras-activated prostate cancer model
7
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