Small molecules which reverse HTT CAG knock in
Canned Analysis
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General Information
AccessionDCA00020218
TitleSmall molecules which reverse HTT CAG knock in
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HTT CAG knock in in the striatum 3~10 weeks cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20e7de467bea600fba7e2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcms
CREEDS IDgene:1282
Cell Typestriatum 3~10 weeks
Gene Symbol (human)HTT
Gene Symbol (mouse)Htt
Organismmouse
Perturbation TypeCAG knock in
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM229429, GSM229430, GSM229431, GSM229435, GSM229436, GSM229437
Perturbed SamplesGSM229432, GSM229433, GSM229434, GSM229438, GSM229439, GSM229440
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9038
Gene Expression Omnibus
Huntington's disease CAG knock-in effect on striatum and cerebellum
24
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