Small molecules which reverse CFTR KO
Canned Analysis
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General Information
AccessionDCA00020222
TitleSmall molecules which reverse CFTR KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CFTR KO in the small intestine tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20e6de467bea600fba7da
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:1285
Cell Typesmall intestine tissue
Gene Symbol (human)CFTR
Gene Symbol (mouse)Cftr
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM11902, GSM11903, GSM11904
Perturbed SamplesGSM11905, GSM11906, GSM11910
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE765
Gene Expression Omnibus
Cystic fibrosis and small intestine
12
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