Small molecules which reverse RUNX1 KD
Canned Analysis
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General Information
AccessionDCA00020228
TitleSmall molecules which reverse RUNX1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RUNX1 KD in the Analysis of ETV6/RUNX1 (E/R) fusion gene-positive in BCP ALL cell lines (REH) following E/R knockdown cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20e53e467bea600fba7ce
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:1288
Cell TypeAnalysis of ETV6/RUNX1 (E/R) fusion gene-positive in BCP ALL cell lines (REH) following E/R knockdown
Gene Symbol (human)RUNX1
Gene Symbol (mouse)Runx1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM734477, GSM734479, GSM734481
Perturbed SamplesGSM734478, GSM734480, GSM734482
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE29639
Gene Expression Omnibus
Leukemia-specific fusion gene ETV6/RUNX1 knockdown effect on ETV6/RUNX1-positive, B-cell precursor acute lymphoblastic leukemia cell lines
14
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