Small molecules which reverse ALK KD
Canned Analysis
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General Information
AccessionDCA00020234
TitleSmall molecules which reverse ALK KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ALK KD in the DAOY medulloblastoma cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23674e467bea600fbb940
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:132
Cell TypeDAOY medulloblastoma cells
Gene Symbol (human)ALK
Gene Symbol (mouse)Alk
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM182018, GSM182019, GSM182020
Perturbed SamplesGSM182015, GSM182016, GSM182017
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE7578
Gene Expression Omnibus
Transcriptional regulators Bmi-1 and Mel-18 depletion effect on medulloblastoma cell line
21
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