Small molecules which reverse CDK4 Heterozygotic knockout (Cdk4 +/-)
Canned Analysis
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General Information
AccessionDCA00020240
TitleSmall molecules which reverse CDK4 Heterozygotic knockout (Cdk4 +/-)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CDK4 Heterozygotic knockout (Cdk4 +/-) in the embryonic stem (ES) cell lines cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2343ae467bea600fbb844
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:1291
Cell Typeembryonic stem (ES) cell lines
Gene Symbol (human)CDK4
Gene Symbol (mouse)Cdk4
Organismmouse
Perturbation TypeHeterozygotic knockout (Cdk4 +/-)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM9272, GSM9273, GSM9274, GSM9275, GSM9276, GSM9277
Perturbed SamplesGSM9278, GSM9279, GSM9280
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE614
Gene Expression Omnibus
Embryonic stem cell cholesterol metabolism mutants
35
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