Small molecules which reverse LMNA LMNA H222P heterozygous knock in mutation
Canned Analysis
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General Information
AccessionDCA00020294
TitleSmall molecules which reverse LMNA LMNA H222P heterozygous knock in mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by LMNA LMNA H222P heterozygous knock in mutation in the heart cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23023e467bea600fbb67a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcms
CREEDS IDgene:1312
Cell Typeheart
Gene Symbol (human)LMNA
Gene Symbol (mouse)Lmna
Organismmouse
Perturbation TypeLMNA H222P heterozygous knock in mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM147451, GSM147452, GSM147459, GSM147460, GSM147461, GSM147462, GSM147463, GSM147465
Perturbed SamplesGSM147506, GSM147507, GSM147509, GSM147510, GSM147511, GSM147512, GSM147513
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6397
Gene Expression Omnibus
Comparison between gene expression in heart from Lmna H222P heterozygous and control mice
5
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