Small molecules which reverse PTEN KO
Canned Analysis
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General Information
AccessionDCA00020300
TitleSmall molecules which reverse PTEN KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PTEN KO in the Analysis of intestinal polyps cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22fffe467bea600fbb66a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:1317
Cell TypeAnalysis of intestinal polyps
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismmouse
Perturbation TypeKO
None{u'vals': [0.0604696268206, -0.0591779487998, -0.0563002625083, -0.0497403276561, -0.048770878779, -0.0477447658994, -0.0477113998993, -0.0450285425963, 0.0449373508174, 0.0439512816351, -0.0428631315504, -0.0405132211202, -0.0381919050739, -0.03797475351
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM140792, GSM140816
Perturbed SamplesGSM140813, GSM140817, GSM140818
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6078
Gene Expression Omnibus
Intestinal polyposis model
12
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