Small molecules which mimic HNF4A KD
Canned Analysis
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General Information
AccessionDCA00020375
TitleSmall molecules which mimic HNF4A KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by HNF4A KD in the hepatic differentiated from ES cell cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d219d7e467bea600fbacd8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1357
Cell Typehepatic differentiated from ES cell
Gene Symbol (human)HNF4A
Gene Symbol (mouse)Hnf4a
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM624094, GSM624095, GSM624096
Perturbed SamplesGSM624098, GSM624099, GSM624100
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE25417
Gene Expression Omnibus
HNF4A deficiency effect on embryonic stem cell model of hepatocyte differentiation
7
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