Small molecules which mimic DDIT3 knock-out (treated with 2 ug/ml tunicamycin for 8 hours)
Canned Analysis
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General Information
AccessionDCA00020433
TitleSmall molecules which mimic DDIT3 knock-out (treated with 2 ug/ml tunicamycin for 8 hours)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by DDIT3 knock-out (treated with 2 ug/ml tunicamycin for 8 hours) in the embryonic fibroblast cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d208afe467bea600fba54c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsolomoniyi
CREEDS IDgene:1388
Cell Typeembryonic fibroblast
Gene Symbol (human)DDIT3
Gene Symbol (mouse)Ddit3
Organismmouse
Perturbation Typeknock-out (treated with 2 ug/ml tunicamycin for 8 hours)
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM37669, GSM37670, GSM37671, GSM37672
Perturbed SamplesGSM37673, GSM37674, GSM37675, GSM37676
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2082
Gene Expression Omnibus
Transcription factor CHOP null mutation effect on fibroblasts subjected to ER stress: time course
21
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