Small molecules which reverse HIF1A KO
Canned Analysis
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General Information
AccessionDCA00020446
TitleSmall molecules which reverse HIF1A KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HIF1A KO in the leukemia stem cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2270be467bea600fbb272
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1406
Cell Typeleukemia stem cells
Gene Symbol (human)HIF1A
Gene Symbol (mouse)Hif1a
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM862186, GSM862188
Perturbed SamplesGSM862187, GSM862189
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE35111
Gene Expression Omnibus
Gene expression profiling in BCR/ABL-expressing LSCs and BCR/ABL-expressing Hif1a-/-LSCs
7
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