Small molecules which mimic NOTCH3 KD
Canned Analysis
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General Information
AccessionDCA00020451
TitleSmall molecules which mimic NOTCH3 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by NOTCH3 KD in the esophageal keratinocytes EPC2-hTERT cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d212c9e467bea600fba9c0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1410
Cell Typeesophageal keratinocytes EPC2-hTERT
Gene Symbol (human)NOTCH3
Gene Symbol (mouse)Notch3
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM678014, GSM678015, GSM678016
Perturbed SamplesGSM678017, GSM678018, GSM678019
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE27424
Gene Expression Omnibus
NOTCH3 knockdown in non-transformed human esophageal cells
14
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