Small molecules which reverse HES6 OE
Canned Analysis
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General Information
AccessionDCA00020500
TitleSmall molecules which reverse HES6 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HES6 OE in the castrate-resistant prostate cancer (xenografts) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d235a2e467bea600fbb8e4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1432
Cell Typecastrate-resistant prostate cancer (xenografts)
Gene Symbol (human)HES6
Gene Symbol (mouse)Hes6
Organismmouse
Perturbation TypeOE
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM893318, GSM893319, GSM893320, GSM893321, GSM893322
Perturbed SamplesGSM893313, GSM893314, GSM893315, GSM893316, GSM893317
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36433
Gene Expression Omnibus
Hes6 expression is controlled by c-Myc and the AR to promote E2F1 activity and poor outcome in castrate-resistant prostate cancer (xenografts)
7
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