Small molecules which reverse RAP1A Rap1a mutant ile312val
Canned Analysis
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General Information
AccessionDCA00020530
TitleSmall molecules which reverse RAP1A Rap1a mutant ile312val
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RAP1A Rap1a mutant ile312val in the embryonic fibroblasts, day E13.5 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23baee467bea600fbbb8e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1445
Cell Typeembryonic fibroblasts, day E13.5
Gene Symbol (human)RAP1A
Gene Symbol (mouse)Rap1a
Organismmouse
Perturbation TypeRap1a mutant ile312val
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1126371, GSM1126372, GSM1126373
Perturbed SamplesGSM1126377, GSM1126378, GSM1126379
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE46209
Gene Expression Omnibus
Non-telomeric role for Rap1 in regulating metabolism and protecting against obesity
28
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