Small molecules which reverse RUNX1 KO
Canned Analysis
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General Information
AccessionDCA00020532
TitleSmall molecules which reverse RUNX1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RUNX1 KO in the embryonic stem cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23bcae467bea600fbbb9a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1446
Cell Typeembryonic stem cells
Gene Symbol (human)RUNX1
Gene Symbol (mouse)Runx1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1142296, GSM1142297, GSM1142298
Perturbed SamplesGSM1142299, GSM1142300, GSM1142301
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE46970
Gene Expression Omnibus
Gene expression of 4, 5, and 6 days differentiated Flk1+ WT ES cells, and of 6 days differentiated Flk1+ Runx1-/- and Tal-1-/- ES cells
14
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