Small molecules which reverse AHR low-affinity mutant
Canned Analysis
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General Information
AccessionDCA00020564
TitleSmall molecules which reverse AHR low-affinity mutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by AHR low-affinity mutant in the bone marrow derived mast cells (BMMCs) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f6bbe467bea600fb9da8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1467
Cell Typebone marrow derived mast cells (BMMCs)
Gene Symbol (human)AHR
Gene Symbol (mouse)Ahr
Organismmouse
Perturbation Typelow-affinity mutant
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1089253, GSM1089254, GSM1089255
Perturbed SamplesGSM1089247, GSM1089248, GSM1089249
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44715
Gene Expression Omnibus
Mast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
14
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