Small molecules which reverse ATF6 tamoxifen-induced activation
Canned Analysis
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General Information
AccessionDCA00020572
TitleSmall molecules which reverse ATF6 tamoxifen-induced activation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ATF6 tamoxifen-induced activation in the heart left ventricle cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fd8fe467bea600fba066
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1473
Cell Typeheart left ventricle
Gene Symbol (human)ATF6
Gene Symbol (mouse)Atf6
Organismmouse
Perturbation Typetamoxifen-induced activation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM206351, GSM206352, GSM206353
Perturbed SamplesGSM205922, GSM205923, GSM206335
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8322
Gene Expression Omnibus
Transgenic model of selective ATF6 activation: heart
7
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