Small molecules which reverse PARP2 KO
Canned Analysis
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General Information
AccessionDCA00020574
TitleSmall molecules which reverse PARP2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PARP2 KO in the sorted Ter119+CD71+ bone marrow cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fd60e467bea600fba050
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1474
Cell Typesorted Ter119+CD71+ bone marrow cells
Gene Symbol (human)PARP2
Gene Symbol (mouse)Parp2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1325331, GSM1325332
Perturbed SamplesGSM1325333, GSM1325334
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54864
Gene Expression Omnibus
Parp-2 is required for efficient erythropoiesis in mice by limiting replicative stress in erythroid progenitors
7
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