Small molecules which mimic EED KO
Canned Analysis
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General Information
AccessionDCA00020583
TitleSmall molecules which mimic EED KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by EED KO in the Eed KO E14 ESCs on day 0 (undifferentiated) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f99ee467bea600fb9eae
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1480
Cell TypeEed KO E14 ESCs on day 0 (undifferentiated)
Gene Symbol (human)EED
Gene Symbol (mouse)Eed
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1197056, GSM1197068
Perturbed SamplesGSM1197053, GSM1197065
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE49305
Gene Expression Omnibus
Polycomb protein EED is required for selective silencing of pluripotency genes upon ESC differentiation
42
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