Small molecules which reverse EED KO
Canned Analysis
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General Information
AccessionDCA00020586
TitleSmall molecules which reverse EED KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by EED KO in the Eed KO J1 ESCs on day 3 EB differentiation cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f997e467bea600fb9eac
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1481
Cell TypeEed KO J1 ESCs on day 3 EB differentiation
Gene Symbol (human)EED
Gene Symbol (mouse)Eed
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1197060, GSM1197072
Perturbed SamplesGSM1197057, GSM1197069
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE49305
Gene Expression Omnibus
Polycomb protein EED is required for selective silencing of pluripotency genes upon ESC differentiation
42
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