Small molecules which reverse RUNX1 KO
Canned Analysis
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General Information
AccessionDCA00020606
TitleSmall molecules which reverse RUNX1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RUNX1 KO in the Analysis of c-Kit+Sca-1+Lin- hematopoietic stem cells (HSCs) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ffd9e467bea600fba168
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:1492
Cell TypeAnalysis of c-Kit+Sca-1+Lin- hematopoietic stem cells (HSCs)
Gene Symbol (human)RUNX1
Gene Symbol (mouse)Runx1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM986468, GSM986469, GSM986470
Perturbed SamplesGSM986471, GSM986472, GSM986473
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40155
Gene Expression Omnibus
Runt homology domain expression effect on hematopoietic stem cells
7
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