Small molecules which mimic PBRM1 KO
Canned Analysis
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General Information
AccessionDCA00020609
TitleSmall molecules which mimic PBRM1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PBRM1 KO in the Clear-cell renal cell carcinoma tumor (VHL inactivated) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2000be467bea600fba17e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1494
Cell TypeClear-cell renal cell carcinoma tumor (VHL inactivated)
Gene Symbol (human)PBRM1
Gene Symbol (mouse)Pbrm1
Organismhuman
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM904989, GSM905002, GSM905009, GSM905014, GSM905020, GSM905023, GSM905029, GSM905034
Perturbed SamplesGSM904991, GSM904994, GSM904996, GSM905007, GSM905012, GSM905022, GSM905026, GSM905027, GSM905031, GSM905036, GSM905041, GSM905044
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36895
Gene Expression Omnibus
Clear-cell renal cell carcinoma tumors and tumorgrafts deficient for tumor suppressor BAP1 or PBRM1
21
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