Small molecules which mimic TCOF1 KD
Canned Analysis
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General Information
AccessionDCA00020617
TitleSmall molecules which mimic TCOF1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by TCOF1 KD in the whole embryo cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20002e467bea600fba17a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1497
Cell Typewhole embryo
Gene Symbol (human)TCOF1
Gene Symbol (mouse)Tcof1
Organismmouse
Perturbation TypeKD
None{u'vals': [-0.0439191990483, -0.0428199541935, -0.0410852407868, -0.0392285500481, 0.0391641104578, 0.0381357666616, 0.0380955628599, -0.0366854218735, -0.0366429672105, 0.0365013809757, 0.0356576919535, -0.0354671444026, 0.0353769988836, 0.033686321555,
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM257052, GSM257054, GSM257056
Perturbed SamplesGSM257053, GSM257055, GSM257057
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE10167
Gene Expression Omnibus
Treacher Collins Syndrome gene heterozygous mutation effect on embryos
12
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