Small molecules which reverse PIK3CA Mutation
Canned Analysis
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General Information
AccessionDCA00020628
TitleSmall molecules which reverse PIK3CA Mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PIK3CA Mutation in the Analysis of estrogen receptor α-positive (ERα+) breast tumors cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d220aee467bea600fbafa6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:1502
Cell TypeAnalysis of estrogen receptor α-positive (ERα+) breast tumors
Gene Symbol (human)PIK3CA
Gene Symbol (mouse)Pik3ca
Organismhuman
Perturbation TypeMutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM547768, GSM547769, GSM547770, GSM547771, GSM547776, GSM547779, GSM547780, GSM547781, GSM547782, GSM547784, GSM547785, GSM547786, GSM547787, GSM547788, GSM547789, GSM547790, GSM547791, GSM547793, GSM547795, GSM547796, GSM547797, GSM547798, GSM547801, GS
Perturbed SamplesGSM547772, GSM547773, GSM547774, GSM547775, GSM547777, GSM547778, GSM547783, GSM547792, GSM547794, GSM547799, GSM547800, GSM547806, GSM547807, GSM547809
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE22035
Gene Expression Omnibus
Postmenopausal estrogen receptor -positive breast tumor with PIK3CA mutation
14
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