Small molecules which mimic PIK3CA mutant
Canned Analysis
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General Information
AccessionDCA00020629
TitleSmall molecules which mimic PIK3CA mutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PIK3CA mutant in the ER+ breast tumor cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fb60e467bea600fb9f72
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1873
Cell TypeER+ breast tumor
Gene Symbol (human)PIK3CA
Gene Symbol (mouse)Pik3ca
Organismhuman
Perturbation Typemutant
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM547768, GSM547769, GSM547770, GSM547771, GSM547776, GSM547779, GSM547780, GSM547781, GSM547782, GSM547784, GSM547785, GSM547786, GSM547787, GSM547788, GSM547789, GSM547790, GSM547791, GSM547793, GSM547795, GSM547796, GSM547797, GSM547798, GSM547801, GS
Perturbed SamplesGSM547772, GSM547773, GSM547774, GSM547775, GSM547777, GSM547778, GSM547783, GSM547792, GSM547794, GSM547799, GSM547800, GSM547806, GSM547807, GSM547809
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE22035
Gene Expression Omnibus
Postmenopausal estrogen receptor -positive breast tumor with PIK3CA mutation
14
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