Small molecules which reverse LMNA KO
Canned Analysis
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General Information
AccessionDCA00020650
TitleSmall molecules which reverse LMNA KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by LMNA KO in the whole heart cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21a47e467bea600fbad0a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1518
Cell Typewhole heart
Gene Symbol (human)LMNA
Gene Symbol (mouse)Lmna
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM147451, GSM147452, GSM147459, GSM147460, GSM147461, GSM147462, GSM147463, GSM147465
Perturbed SamplesGSM147514, GSM147515, GSM147516, GSM147517, GSM147518, GSM147519
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8000
Gene Expression Omnibus
Lmna H222P homozygous and heterozygous mutant models of Emery-Dreifuss muscular dystrophy: hearts
19
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