Small molecules which reverse STAT1 KO
Canned Analysis
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General Information
AccessionDCA00020652
TitleSmall molecules which reverse STAT1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by STAT1 KO in the bone marrow macrophages (BMMs) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21a3ee467bea600fbad06
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1519
Cell Typebone marrow macrophages (BMMs)
Gene Symbol (human)STAT1
Gene Symbol (mouse)Stat1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1190948, GSM1190952, GSM1190956
Perturbed SamplesGSM1190947, GSM1190951, GSM1190955
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48970
Gene Expression Omnibus
Contribution of the STAT1alpha and STAT1beta isoforms to IFN-gamma mediated innate immunity
21
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