Small molecules which reverse BATF KO
Canned Analysis
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General Information
AccessionDCA00020662
TitleSmall molecules which reverse BATF KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by BATF KO in the 3 day in vitro effector CD8+ T cells--Naïve CD8+ T cells (P14 TCR transgenic C57Bl/6) were stimulated with plate-bound anti-CD3 (4 mg/ml, clone 2C11, BD Pharmingen) and anti-CD28 (4 mg/ml, clone 37.51, BD Pharmingen) in the presence of recombinant human IL-2 (100 U/ml, R&D Systems) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21394e467bea600fbaa1a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1523
Cell Type3 day in vitro effector CD8+ T cells--Naïve CD8+ T cells (P14 TCR transgenic C57Bl/6) were stimulated with plate-bound anti-CD3 (4 mg/ml, clone 2C11, BD Pharmingen) and anti-CD28 (4 mg/ml, clone 37.51, BD Pharmingen) in the presence of recomb
Gene Symbol (human)BATF
Gene Symbol (mouse)Batf
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1310344, GSM1310345, GSM1310346, GSM1310347
Perturbed SamplesGSM1310348, GSM1310349, GSM1310350, GSM1310351
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54215
Gene Expression Omnibus
Comparison of gene expression profiles of nave and in vitro effector CD8+ T cells from wild-type and BATF-/- mice
14
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