Small molecules which reverse TLR4 mutation
Canned Analysis
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General Information
AccessionDCA00020682
TitleSmall molecules which reverse TLR4 mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TLR4 mutation in the lung cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20e40e467bea600fba7c6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1534
Cell Typelung
Gene Symbol (human)TLR4
Gene Symbol (mouse)Tlr4
Organismmouse
Perturbation Typemutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM4018, GSM4019
Perturbed SamplesGSM4014, GSM4015
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE476
Gene Expression Omnibus
Ozone effect on airways hyperpermeability
14
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