Small molecules which mimic ITK KO
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00020723
TitleSmall molecules which mimic ITK KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by ITK KO in the unstimulated CD3+ T-cells (pooled thymus and spleen) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22fa4e467bea600fbb640
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1554
Cell Typeunstimulated CD3+ T-cells (pooled thymus and spleen)
Gene Symbol (human)ITK
Gene Symbol (mouse)Itk
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM313166, GSM313167, GSM313168
Perturbed SamplesGSM313169, GSM313170
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12466
Gene Expression Omnibus
Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.