Small molecules which mimic IL6 anti-IL6 monoclonal antibody, neutralization
Canned Analysis
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General Information
AccessionDCA00020725
TitleSmall molecules which mimic IL6 anti-IL6 monoclonal antibody, neutralization
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by IL6 anti-IL6 monoclonal antibody, neutralization in the Xenograft tumors from DU145 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23b21e467bea600fbbb4c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1555
Cell TypeXenograft tumors from DU145
Gene Symbol (human)IL6
Gene Symbol (mouse)Il6
Organismhuman
Perturbation Typeanti-IL6 monoclonal antibody, neutralization
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1536778, GSM1536779, GSM1536780
Perturbed SamplesGSM1536775, GSM1536776, GSM1536777
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE62941
Gene Expression Omnibus
Inhibition of Interleukin-6 (IL-6) Signaling and Tumor Growth by a Human Neutralizing Anti-IL-6 Antibody with a Prolonged Half-Life
21
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