Small molecules which mimic IL6 anti-IL6 monoclonal antibody, neutralization
Canned Analysis
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General Information
AccessionDCA00020727
TitleSmall molecules which mimic IL6 anti-IL6 monoclonal antibody, neutralization
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by IL6 anti-IL6 monoclonal antibody, neutralization in the Xenograft tumors from NCI-H1650 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23b18e467bea600fbbb48
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1556
Cell TypeXenograft tumors from NCI-H1650
Gene Symbol (human)IL6
Gene Symbol (mouse)Il6
Organismhuman
Perturbation Typeanti-IL6 monoclonal antibody, neutralization
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1536784, GSM1536785, GSM1536786
Perturbed SamplesGSM1536781, GSM1536782, GSM1536783
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE62941
Gene Expression Omnibus
Inhibition of Interleukin-6 (IL-6) Signaling and Tumor Growth by a Human Neutralizing Anti-IL-6 Antibody with a Prolonged Half-Life
21
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