Small molecules which reverse IL6 anti-IL6 monoclonal antibody, neutralization
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00020730
TitleSmall molecules which reverse IL6 anti-IL6 monoclonal antibody, neutralization
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IL6 anti-IL6 monoclonal antibody, neutralization in the Xenograft tumors from KPL4 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23b11e467bea600fbbb46
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1557
Cell TypeXenograft tumors from KPL4
Gene Symbol (human)IL6
Gene Symbol (mouse)Il6
Organismhuman
Perturbation Typeanti-IL6 monoclonal antibody, neutralization
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1536790, GSM1536791, GSM1536792
Perturbed SamplesGSM1536787, GSM1536788, GSM1536789
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE62941
Gene Expression Omnibus
Inhibition of Interleukin-6 (IL-6) Signaling and Tumor Growth by a Human Neutralizing Anti-IL-6 Antibody with a Prolonged Half-Life
21
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.