Small molecules which reverse HTT Gain of function by knock in of htt cag repeat length: 7/85
Canned Analysis
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General Information
AccessionDCA00020792
TitleSmall molecules which reverse HTT Gain of function by knock in of htt cag repeat length: 7/85
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HTT Gain of function by knock in of htt cag repeat length: 7/85 in the ES cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20d97e467bea600fba77a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1627
Cell TypeES cells
Gene Symbol (human)HTT
Gene Symbol (mouse)Htt
Organismmouse
Perturbation TypeGain of function by knock in of htt cag repeat length: 7/85
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM638129, GSM638130, GSM638131, GSM638132, GSM638133, GSM638134
Perturbed SamplesGSM638147, GSM638148, GSM638149
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26001
Gene Expression Omnibus
Huntington's disease Hdh knock-out and knock-in embryonic stem cells
80
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