Small molecules which mimic OTX2 silencing
Canned Analysis
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General Information
AccessionDCA00020811
TitleSmall molecules which mimic OTX2 silencing
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by OTX2 silencing in the D425 medulloblastoma (MB) cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21b80e467bea600fbad90
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:163
Cell TypeD425 medulloblastoma (MB) cells
Gene Symbol (human)OTX2
Gene Symbol (mouse)Otx2
Organismhuman
Perturbation Typesilencing
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM565194, GSM565195, GSM565196, GSM565197, GSM565198, GSM565199
Perturbed SamplesGSM565176, GSM565177, GSM565178, GSM565179, GSM565180, GSM565181, GSM565182, GSM565183, GSM565184, GSM565185, GSM565186, GSM565187, GSM565188, GSM565189, GSM565190, GSM565191, GSM565192, GSM565193
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE22875
Gene Expression Omnibus
Transcription factor OTX2 oncogene silencing effect on D425 medulloblastoma cell line: time course
7
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