Small molecules which mimic AIRE KO
Canned Analysis
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General Information
AccessionDCA00020865
TitleSmall molecules which mimic AIRE KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by AIRE KO in the regulatory T cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fdeae467bea600fba08c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1676
Cell Typeregulatory T cells
Gene Symbol (human)AIRE
Gene Symbol (mouse)Aire
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM745923, GSM745927, GSM745931
Perturbed SamplesGSM745922, GSM745926, GSM745930
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE30129
Gene Expression Omnibus
Activated Autoimmune Regulator (AIRE)-deficient, CD8+CD28low regulatory T lymphocytes
7
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