Small molecules which reverse CHRNA4 KO
Canned Analysis
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General Information
AccessionDCA00020966
TitleSmall molecules which reverse CHRNA4 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CHRNA4 KO in the whole brain (mutation beta4 -/-) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2098ce467bea600fba5ae
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1725
Cell Typewhole brain (mutation beta4 -/-)
Gene Symbol (human)CHRNA4
Gene Symbol (mouse)Chrna4
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM153512, GSM153526, GSM153527, GSM153528, GSM153532, GSM153533
Perturbed SamplesGSM153567, GSM153568, GSM153569, GSM153570, GSM153571
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6614
Gene Expression Omnibus
Seizure model: brain
21
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