Small molecules which mimic PPARG V290M dominant negative mutation
Canned Analysis
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General Information
AccessionDCA00020967
TitleSmall molecules which mimic PPARG V290M dominant negative mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PPARG V290M dominant negative mutation in the Primary aortic endothelial cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20992e467bea600fba5b0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1726
Cell TypePrimary aortic endothelial cells
Gene Symbol (human)PPARG
Gene Symbol (mouse)Pparg
Organismmouse
Perturbation TypeV290M dominant negative mutation
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM299778, GSM299779, GSM299780
Perturbed SamplesGSM299781, GSM299782, GSM299783
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11870
Gene Expression Omnibus
Aortic endothelial cell response to dominant negative PPAR gamma expression in vitro
7
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