Small molecules which mimic TP53 KD
Canned Analysis
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General Information
AccessionDCA00021089
TitleSmall molecules which mimic TP53 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by TP53 KD in the HEK293 cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22b75e467bea600fbb468
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1784
Cell TypeHEK293 cells
Gene Symbol (human)TP53
Gene Symbol (mouse)Trp53
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM28627, GSM28628, GSM28629
Perturbed SamplesGSM28651, GSM28652, GSM28653
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1676
Gene Expression Omnibus
siRNA knockdown and transcriptional response to DNA damage
35
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