Small molecules which reverse HDAC1 Drug inhibition (0.5mM VPA for 4 hs)
Canned Analysis
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General Information
AccessionDCA00021134
TitleSmall molecules which reverse HDAC1 Drug inhibition (0.5mM VPA for 4 hs)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HDAC1 Drug inhibition (0.5mM VPA for 4 hs) in the ES cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d201f0e467bea600fba256
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1803
Cell TypeES cells
Gene Symbol (human)HDAC1
Gene Symbol (mouse)Hdac1
Organismmouse
Perturbation TypeDrug inhibition (0.5mM VPA for 4 hs)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM590265, GSM590266
Perturbed SamplesGSM590267, GSM590268
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23957
Gene Expression Omnibus
Gene expression profiles of E14 ESCs treated with low levels of the HDAC inhibitor VPA for 4 hrs
7
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