Small molecules which reverse IPMK KD
Canned Analysis
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General Information
AccessionDCA00021162
TitleSmall molecules which reverse IPMK KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IPMK KD in the cell line: Breast carcinoma cell line Cal51, samples were treated with DNA crosslinking reagent mitomycin C (MMC) for 24h prior to harvest cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d206b3e467bea600fba46e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1814
Cell Typecell line: Breast carcinoma cell line Cal51, samples were treated with DNA crosslinking reagent mitomycin C (MMC) for 24h prior to harvest
Gene Symbol (human)IPMK
Gene Symbol (mouse)Ipmk
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1204537, GSM1204538, GSM1204539
Perturbed SamplesGSM1204543, GSM1204544, GSM1204545
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE49658
Gene Expression Omnibus
Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity
14
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