Small molecules which reverse MYC myc +/- vs. WT
Canned Analysis
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General Information
AccessionDCA00021170
TitleSmall molecules which reverse MYC myc +/- vs. WT
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MYC myc +/- vs. WT in the liver, 24 months cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20af9e467bea600fba64e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1820
Cell Typeliver, 24 months
Gene Symbol (human)MYC
Gene Symbol (mouse)Myc
Organismmouse
Perturbation Typemyc +/- vs. WT
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1333073, GSM1333074, GSM1333075
Perturbed SamplesGSM1333091, GSM1333092, GSM1333093
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55272
Gene Expression Omnibus
Reduced Expression of the Proto-oncogene Myc Increases Mouse Longevity and Enhances Healthspan
42
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