Small molecules which reverse TP53 KO
Canned Analysis
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General Information
AccessionDCA00021192
TitleSmall molecules which reverse TP53 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TP53 KO in the mammary epithelial cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20b36e467bea600fba66a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1829
Cell Typemammary epithelial cells
Gene Symbol (human)TP53
Gene Symbol (mouse)Trp53
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM996029, GSM996030, GSM996031
Perturbed SamplesGSM996032, GSM996033, GSM996034
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE40545
Gene Expression Omnibus
RB pathway deregulation promotes invasion and disease progression in a mouse model of MYC-overexpressing mammary tumorigenesis
7
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