Small molecules which reverse ZAP70 knockout
Canned Analysis
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General Information
AccessionDCA00021256
TitleSmall molecules which reverse ZAP70 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ZAP70 knockout in the Jurkat cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f5ece467bea600fb9d4c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1869
Cell TypeJurkat
Gene Symbol (human)ZAP70
Gene Symbol (mouse)Zap70
Organismhuman
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM89759, GSM89760, GSM89764
Perturbed SamplesGSM89754, GSM89769, GSM89772
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3922
Gene Expression Omnibus
T cell receptor-independent basal signaling in unstimulated Jurkat T cells
14
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