Small molecules which reverse IGF1R druginhibition
Canned Analysis
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General Information
AccessionDCA00021276
TitleSmall molecules which reverse IGF1R druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IGF1R druginhibition in the 3T3 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2253fe467bea600fbb1a6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1886
Cell Type3T3
Gene Symbol (human)IGF1R
Gene Symbol (mouse)Igf1r
Organismmouse
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM352188, GSM352189, GSM352190
Perturbed SamplesGSM352191, GSM352192, GSM352193
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE14024
Gene Expression Omnibus
Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.
14
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