Small molecules which reverse TBK1 knockdown
Canned Analysis
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General Information
AccessionDCA00021288
TitleSmall molecules which reverse TBK1 knockdown
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TBK1 knockdown in the lung epithelial cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22a0de467bea600fbb3ca
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1890
Cell Typelung epithelial cell line
Gene Symbol (human)TBK1
Gene Symbol (mouse)Tbk1
Organismhuman
Perturbation Typeknockdown
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM440271, GSM440272, GSM440273, GSM440274, GSM440275, GSM440276
Perturbed SamplesGSM440268, GSM440269, GSM440270
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17643
Gene Expression Omnibus
Profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression
21
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