Small molecules which reverse KRAS oncogenic KRAS mutation
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00021292
TitleSmall molecules which reverse KRAS oncogenic KRAS mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by KRAS oncogenic KRAS mutation in the AALE cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20a66e467bea600fba60e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorBodolino
CREEDS IDgene:2625
Cell TypeAALE cells
Gene Symbol (human)KRAS
Gene Symbol (mouse)Kras
Organismhuman
Perturbation Typeoncogenic KRAS mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM440274, GSM440275, GSM440276
Perturbed SamplesGSM440265, GSM440266, GSM440267
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17643
Gene Expression Omnibus
Profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression
21
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.