Small molecules which reverse KIT activemutant
Canned Analysis
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General Information
AccessionDCA00021296
TitleSmall molecules which reverse KIT activemutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by KIT activemutant in the gastrointestinal stromal tumors cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22a04e467bea600fbb3c6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1892
Cell Typegastrointestinal stromal tumors
Gene Symbol (human)KIT
Gene Symbol (mouse)Kit
Organismhuman
Perturbation Typeactivemutant
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM442943, GSM442944, GSM442951
Perturbed SamplesGSM442936, GSM442937, GSM442938, GSM442940, GSM442941, GSM442942, GSM442945, GSM442946, GSM442954, GSM442957, GSM442958, GSM442959, GSM442960, GSM442962, GSM442964
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17743
Gene Expression Omnibus
Gene expression profiles differentiating gastrointestinal stromal tumours according to KIT mutations and expression
14
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